Azole resistance in A. fumigatus great concern

Azole resistance in A. fumigatus is a great concern. Reference susceptibility testing is technical challenging and not broadly nor timely available. A recently published multicentre study demonstrate the excellent performance of the azole screening agar test (originally developed by PE Verweij). Despite challenging the test with a blinded set of 40 mutants (involving alterations in 4 different codons) and 40 wild type isolates and also simulated mixed cultures with only 1 in 5 mutant colonies, reliable discrimination between azole resistant and susceptible infections were found. The test will be officially adopted as a EUCAST screening test and its use and availability is a great step forward allowing early detection of azole resistant A. fumigatus. Read more at: https://academic.oup.com/jac/article-abstract/doi/10.1093/jac/dkx319/4339346/Multicentre-validation-of-4-well-azole-agar-plates?redirectedFrom=fulltext