Azole resistance in A. fumigatus great concern


Azole resistance in A. fumigatus is a great concern. Reference susceptibility testing is technical challenging and not broadly nor timely available. A recently published multicentre study demonstrate the excellent performance of the azole screening agar test (originally developed by PE Verweij). Despite challenging the test with a blinded set of 40 mutants (involving alterations in 4 different codons) and 40 wild type isolates and also simulated mixed cultures with only 1 in 5 mutant colonies, reliable discrimination between azole resistant and susceptible infections were found. The test will be officially adopted as a EUCAST screening test and its use and availability is a great step forward allowing early detection of azole resistant A. fumigatus. Read more at:


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